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Article

Triple point-mutants of hypoxia-inducible factor-1α accelerate in vivo angiogenesis in bone defect regions.

Cell biochemistry and biophysics - 1 Nov 2013

Li Chen, Liu Danping, Zhang Zheng, Wang Guoxian, Xu Na

Abstract excerpt

To investigate the functions of triple point-mutants of hypoxia-inducible factor 1α (HIF1α) in angiogenesis in bone defect regions under normoxic conditions. 1. Triple point-mutations (in amino acids 402, 564, and 803) in the HIF1α coding sequence (CDS) were induced by polymerase chain reaction. The triple mutant HIF1α (402/564/803) was inserted into the adenovirus pAdEasy-1 system for complete viral packaging...

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Identifiers

PMID: 23475394
DOI: 10.1007/s12013-013-9541-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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