Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adenovirus-mediated hypoxia-inducible factor 1alpha double-mutant promotes differentiation of bone marrow stem cells to cardiomyocytes.

The journal of physiological sciences : JPS - 1 Nov 2009

Wang Yesong, Feng Chong, Xue Jiaojie, Sun Aijiao, Li Jun, Wu Juekan

Abstract excerpt

The hypoxia-inducible factor 1alpha (HIF-1alpha) regulates transcriptional genes involved in cell proliferation, survival, and differentiation. Under normoxia, HIF-1alpha has a short half-life (t((1/2)) approximately 5 min) and low transcriptional activity. An HIF-1alpha mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position 803, can prevent HIF-1alpha...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Cell Culture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Separation

Share to Fluorescent Antibody Technique, Indirect

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Myocytes, Cardiac

Source

Open in PubMed Open full text

Identifiers

PMID: 19603255
DOI: 10.1007/s12576-009-0050-x
PMCID: PMC10717356

Genes

MSC
GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenovirus-mediated hypoxia-inducible factor 1alpha double-mutant promotes differentiation of bone marrow stem cells to cardiomyocytes.PMID 19603255Read ↗

Adenovirus-mediated expression of hypoxia-inducible factor 1α double mutant converts neonatal cardiac fibroblasts into (cardio)myocyte phenotype.Semantic proximity Read ↗

Bone marrow derived stromal cells modified by adenovirus-mediated HIF-1alpha double mutant protect cardiac myocytes against CoCl2-induced apoptosis.Semantic proximity Read ↗

Adenovirus-mediated expression of the HO-1 protein within MSCs decreased cytotoxicity and inhibited apoptosis induced by oxidative stressesSemantic proximity Read ↗

Adenoviral expression of vascular endothelial growth factor splice variants differentially regulate bone marrow‐derived mesenchymal stem cellsSemantic proximity Read ↗

Triple point-mutants of hypoxia-inducible factor-1α accelerate in vivo angiogenesis in bone defect regions.Semantic proximity Read ↗

Hypoxic Preconditioning Enhances Cellular Viability and Migratory Ability: Role of DANCR/miR-656-3p/HIF-1α Axis in Placental Mesenchymal Stem CellsSemantic proximity Read ↗

Construction of human BMP2-IRES-HIF1αmu adenovirus expression vector and its expression in mesenchymal stem cells.Semantic proximity Read ↗

Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins.Semantic proximity Read ↗

Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repairSemantic proximity Read ↗

Chimeric Adeno-Associated Virus-Mediated Cardiovascular Reprogramming for Ischemic Heart DiseaseSemantic proximity Read ↗

HIF-2α and Oct4 have synergistic effects on survival and myocardial repair of very small embryonic-like mesenchymal stem cells in infarcted heartsSemantic proximity Read ↗

Activation of C-transactivation domain is essential for optimal HIF-1 alpha-mediated transcriptional and angiogenic effects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.