Article
Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes.
Human genetics - 1 Jun 2013
Muller Yunhua L, Hanson Robert L, Knowler William C, Fleming Jamie, Goswami Jayita, Huang Ke, Traurig Michael, Sutherland Jeff, Wiedrich Chris, Wiedrich Kim, Mahkee Darin, Ossowski Vicky, Kobes Sayuko, Bogardus Clifton, Baier Leslie J
Abstract excerpt
A prior linkage scan in Pima Indians identified a putative locus for type two diabetes (T2D) and body mass index (BMI) on chromosome 11q23-25. Association mapping across this region identified single nucleotide polymorphisms (SNPs) in the trehalase gene (TREH) that were associated with T2D. To assess the putative connection between trehalase activity and T2D, we performed a linkage study for trehalase activity in...
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