Article
Vitamin D status, filaggrin genotype, and cardiovascular risk factors: a Mendelian randomization approach.
PloS one - 1 Jan 2013
Skaaby Tea, Husemoen Lise Lotte Nystrup, Martinussen Torben, Thyssen Jacob P, Melgaard Michael, Thuesen Betina Heinsbæk, Pisinger Charlotta, Jørgensen Torben, Johansen Jeanne D, Menné Torkil, Carlsen Berit, Szecsi Pal B, Stender Steen, Fenger Runa Vavia, Fenger Mogens, Linneberg Allan
Abstract excerpt
BACKGROUND: Vitamin D deficiency is associated with increased cardiovascular disease risk in observational studies. Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes. We used a Mendelian randomization approach to estimate the causal effect...
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