The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer.

doi:10.1093/carcin/bgt080

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The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer.

Carcinogenesis - 1 Jul 2013

Matsuo Keitaro, Oze Isao, Hosono Satoyo, Ito Hidemi, Watanabe Miki, Ishioka Kuka, Ito Seiji, Tajika Masahiro, Yatabe Yasushi, Niwa Yasumasa, Yamao Kenji, Nakamura Shigeo, Tajima Kazuo, Tanaka Hideo

Abstract excerpt

The impact of alcohol on the risk of stomach cancer is controversial. Although aldehyde dehydrogenase 2 (ALDH2) Glu504Lys (rs671) polymorphism has a strong effect on acetaldehyde metabolism, little is known about its impact on stomach cancer risk when combined with alcohol drinking. This case-control study included a total of 697 incident stomach cancer case subjects and 1372 non-cancer control subjects who...

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PMID: 23455379
DOI: 10.1093/carcin/bgt080

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ALDH2

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