Article
Using population admixture to help complete maps of the human genome.
Nature genetics - 1 Apr 2013
Genovese Giulio, Handsaker Robert E, Li Heng, Altemose Nicolas, Lindgren Amelia M, Chambert Kimberly, Pasaniuc Bogdan, Price Alkes L, Reich David, Morton Cynthia C, Pollak Martin R, Wilson James G, McCarroll Steven A
Abstract excerpt
Tens of millions of base pairs of euchromatic human genome sequence, including many protein-coding genes, have no known location in the human genome. We describe an approach for localizing the human genome's missing pieces using the patterns of genome sequence variation created by population admixture. We mapped the locations of 70 scaffolds spanning 4 million base pairs of the human genome's unplaced euchromatic...
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