Article
High throughput molecular confirmation of β-thalassemia mutations using novel TaqMan probes.
Sensors (Basel, Switzerland) - 18 Feb 2013
Kho Siew Leng, Chua Kek Heng, George Elizabeth, Tan Jin Ai Mary Anne
Abstract excerpt
β-Thalassemia is a public health problem where 4.5% of Malaysians are β-thalassemia carriers. The genetic disorder is caused by defects in the β-globin gene complex which lead to reduced or complete absence of β-globin chain synthesis. Five TaqMan genotyping assays were designed and developed to detect the common β-thalassemia mutations in Malaysian Malays. The assays were evaluated with 219 "blinded" DNA...
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