Article
Genotype-Phenotype Correlation of β-Thalassemia in Malaysian Population: Toward Effective Genetic Counseling.
Hemoglobin - 1 May 2020
Abdullah Uday Y H, Ibrahim Hishamshah M, Mahmud Noraesah Binti, Salleh Mohamad Zaki, Teh Lay Kek, Noorizhab Mohd Nur Fakhruzzaman Bin, Zilfalil Bin Alwi, Jassim Haitham Muhammed, Wilairat Prapin, Fucharoen Suthat
Abstract excerpt
Effective prevention of β-thalassemia (β-thal) requires strategies to detect at-risk couples. This is the first study attempting to assess the prevalence of silent β-thal carriers in the Malaysian population. Hematological and clinical parameters were evaluated in healthy blood donors and patients with β-thal trait, Hb E (HBB: c.79G>A)/β-thal and β-thal major (β-TM). β-Globin gene sequencing was carried out for...
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