Article
Genetic variants in HLA-DP/DQ contribute to risk of cervical cancer: a two-stage study in Chinese women.
Gynecologic oncology - 1 May 2013
Jiang Jie, Li Ni, Shen Yan, Liu Jibin, Liu Li, Du Jiangbo, Lei Yu, Wen Yang, Yang Lin, Guo Lanwei, Zhang Kai, Qiang Fulin, Wang Sumin, Hu Zhibin, Dai Min, Shen Hongbing
Abstract excerpt
OBJECTIVE: Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Herein, we evaluated whether genetic variants of HLA-DP and HLA-DQ are associated with cervical cancer risk. METHODS: We genotyped four single nucleotide polymorphisms (SNPs) in HLA-DP (rs3077 and rs9277535) and HLA-DQ...
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