Article
Targeted therapy for melanoma: rational combinatorial approaches.
Oncogene - 2 Jan 2014
Kwong L N, Davies M A
Abstract excerpt
The treatment of melanoma, the most aggressive form of skin cancer, is being revolutionized by the development of personalized targeted therapy approaches. Mutant-selective BRAF inhibitors and MEK inhibitors have demonstrated impressive clinical results in molecularly selected patients. However, emerging understanding of the molecular heterogeneity of this disease and the identification of multiple mechanisms of...
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