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Article

siRNA down-regulation of FGA mRNA in HepG2 cells demonstrated that heterozygous abnormality of the Aα-chain gene does not affect the plasma fibrinogen level.

Thrombosis research - 1 Apr 2013

Takezawa Yuka, Matsuda Kazuyuki, Terasawa Fumiko, Sugano Mitsutoshi, Honda Takayuki, Okumura Nobuo

Abstract excerpt

INTRODUCTION: We encountered two afibrinogenemia patients with homozygous and compound heterozygous FGA mutation. Of interest, the patients' parents, who are heterozygous, had normal levels of plasma fibrinogen; thus, we hypothesized that liver FGA mRNA levels were higher than those of FGB and/or FGG mRNA. MATERIALS AND METHODS: To test the hypothesis, we quantitated mRNA levels of a normal liver and a human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23414568
DOI: 10.1016/j.thromres.2013.01.010

Genes

FGA
FGG
FGB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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