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Article

Performance comparison of whole-genome sequencing platforms.

Nature biotechnology - 18 Dec 2011

Lam Hugo Y K, Clark Michael J, Chen Rui, Chen Rong, Natsoulis Georges, O'Huallachain Maeve, Dewey Frederick E, Habegger Lukas, Ashley Euan A, Gerstein Mark B, Butte Atul J, Ji Hanlee P, Snyder Michael

Abstract excerpt

Whole-genome sequencing is becoming commonplace, but the accuracy and completeness of variant calling by the most widely used platforms from Illumina and Complete Genomics have not been reported. Here we sequenced the genome of an individual with both technologies to a high average coverage of ∼7...

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PMID: 22178993
DOI: 10.1038/nbt.2065
PMCID: PMC4076012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22178993-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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