Article
Mitochondrial DNA nucleotide changes in primary congenital glaucoma patients.
Molecular vision - 1 Jan 2013
Kumar Manoj, Tanwar Mukesh, Faiq Muneeb Ahmad, Pani Jhumur, Shamsi Monis Bilal, Dada Tanuj, Dada Rima
Abstract excerpt
PURPOSE: Primary congenital glaucoma (PCG) is the second most common cause of blindness, accounting for 0.01%-0.04% of total blindness worldwide. Most congenital glaucoma cases are mapped to the GLC3A locus, and many aspects of PCG are still unknown. Recent studies have reported an increased frequency of mitochondrial DNA (mtDNA) sequence changes in primary open-angle glaucoma, primary angle-closure glaucoma, and...
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