Thyroid hormone receptor alpha gene variants increase the risk of developing obesity and show gene-diet interactions.

doi:10.1038/ijo.2013.11

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Thyroid hormone receptor alpha gene variants increase the risk of developing obesity and show gene-diet interactions.

International journal of obesity (2005) - 1 Nov 2013

Fernández-Real J M, Corella D, Goumidi L, Mercader J M, Valdés S, Rojo Martínez G, Ortega F, Martinez-Larrad M-T, Gómez-Zumaquero J M, Salas-Salvadó J, Martinez González M A, Covas M I, Botas P, Delgado E, Cottel D, Ferrieres J, Amouyel P, Ricart W, Ros E, Meirhaeghe A, Serrano-Rios M, Soriguer F, Estruch R

Abstract excerpt

OBJECTIVE: Thyroid hormone receptor-beta resistance has been associated with metabolic traits. THRA gene sequencing of an obese woman (index case) who presented as empirical thyroid hormone receptor-α (THRA) resistance, disclosed a polymorphism (rs12939700) in a critical region involved in TRα alternative processing. DESIGN AND SUBJECTS: THRA gene variants were evaluated in three independent europid populations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular Diseases

Share to Dietary Fats

Share to Energy Intake

Share to France

Share to Hypothyroidism

Share to Insulin Resistance

Share to Spain

Share to Thyroid Hormone Receptors alpha

Source

Open in PubMed

Identifiers

PMID: 23399772
DOI: 10.1038/ijo.2013.11

Genes

THRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyroid hormone receptor alpha gene variants increase the risk of developing obesity and show gene-diet interactions.PMID 23399772Read ↗

Thyroid hormone resistance syndrome due to mutations in the thyroid hormone receptor α gene (THRA).Semantic proximity Read ↗

Identification and consequences of polymorphisms in the thyroid hormone receptor alpha and beta genes.Semantic proximity Read ↗

Resistance to thyroid hormone, and peroxisome-proliferator-activated receptor gamma resistance.Semantic proximity Read ↗

The rs10401670 variant in resistin gene improved insulin resistance response and metabolic parameters secondaries to weight loss after a hypocaloric diet.Semantic proximity Read ↗

The rs1862513 Variant in Resistin Gene-Modified Insulin Resistance and Insulin Levels after Weight Loss Secondary to Hypocaloric Diet.Semantic proximity Read ↗

Role of resistin (rs7139228) gene polymorphism with metabolic response after a hypocaloric mediterranean diet.Semantic proximity Read ↗

REV-ERB ALPHA polymorphism is associated with obesity in the Spanish obese male population.Semantic proximity Read ↗

Dyslipidemia, Insulin Resistance, Ectopic Lipid Accumulation, and Vascular Function in Resistance to Thyroid Hormone β.Semantic proximity Read ↗

Increased Hepatic Fat Content in Patients with Resistance to Thyroid Hormone Beta.Semantic proximity Read ↗

A Novel Mutation in THRA Gene Associated With an Atypical Phenotype of Resistance to Thyroid Hormone.Semantic proximity Read ↗

Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins.Semantic proximity Read ↗

A resistin gene polymorphism is associated with body mass index in women.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.