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Article

Unraveling the mechanism of protein disaggregation through a ClpB-DnaK interaction.

Science (New York, N.Y.) - 1 Mar 2013

Rosenzweig Rina, Moradi Shoeib, Zarrine-Afsar Arash, Glover John R, Kay Lewis E

Abstract excerpt

HSP-100 protein machines, such as ClpB, play an essential role in reactivating protein aggregates that can otherwise be lethal to cells. Although the players involved are known, including the DnaK/DnaJ/GrpE chaperone system in bacteria, details of the molecular interactions are not well understood. Using methyl-transverse relaxation-optimized nuclear magnetic resonance spectroscopy, we present an...

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Identifiers

PMID: 23393091
DOI: 10.1126/science.1233066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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