Stress response of glioblastoma cells mediated by miR-17-5p targeting PTEN and the passenger strand miR-17-3p targeting MDM2.

Abstract excerpt

Tumor development not only destroys the homeostasis of local tissues but also the whole body, and thus the tumor cells have to face the body's defense system, a shortage of nutrition and oxygen, and chemotherapeutic drug treatment. In response to these stresses, tumor cells often alter gene expression and microRNA levels to facilitate survival. We have demonstrated that glioblastoma cells deprived of nutrition or...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to AC133 Antigen
• Share to Glioblastoma
• Share to Hypoxia-Inducible Factor 1, alpha Subunit