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Article

DNA elements reducing transcriptional gene silencing revealed by a novel screening strategy.

PloS one - 1 Jan 2013

Kishimoto Naoki, Nagai Jun-ichi, Kinoshita Takehito, Ueno Keiichiro, Ohashi Yuko, Mitsuhara Ichiro

Abstract excerpt

Transcriptional gene silencing (TGS)--a phenomenon observed in endogenous genes/transgenes in eukaryotes--is a huge hindrance to transgenic technology and occurs mainly when the genes involved share sequence homology in their promoter regions. TGS depends on chromosomal position, suggesting the existence of genomic elements that suppress TGS. However, no systematic approach to identify such DNA elements has yet...

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Identifiers

PMID: 23382937
DOI: 10.1371/journal.pone.0054670
PMCID: PMC3559876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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