Expression of hemochromatosis in homozygous subjects. Implications for early diagnosis and prevention.

doi:10.1016/0016-5085(90)91100-k

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Article

Expression of hemochromatosis in homozygous subjects. Implications for early diagnosis and prevention.

Gastroenterology - 1 Jun 1990

Powell L W, Summers K M, Board P G, Axelsen E, Webb S, Halliday J W

Abstract excerpt

This study looks at expression of genetic hemochromatosis in the homozygous and heterozygous states. Two hundred nine subjects in 40 families with confirmed hemochromatosis and clear evidence of HLA linkage in symptomatic individuals were studied prospectively for up to 24 yr. The study group consisted of 40 probands, 51 subjects sharing two HLA haplotypes with affected relatives (putative homozygotes), 98...

Topics

Adolescent
Adult
Aged
Chromosomes, Human, Pair 6
Female
Follow-Up Studies
Genetic Linkage
Genetic Markers
Genotype
HLA-A Antigens
HLA-B Antigens
Hemochromatosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Homozygote

Humans

Iron

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 2338199
DOI: 10.1016/0016-5085(90)91100-k

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2338199-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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