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Article

Population pharmacokinetic study of memantine: effects of clinical and genetic factors.

Clinical pharmacokinetics - 1 Mar 2013

Noetzli Muriel, Guidi Monia, Ebbing Karsten, Eyer Stephan, Wilhelm Laurence, Michon Agnès, Thomazic Valérie, Alnawaqil Abdel-Messieh, Maurer Sophie, Zumbach Serge, Giannakopoulos Panteleimon, von Gunten Armin, Csajka Chantal, Eap Chin B

Abstract excerpt

BACKGROUND AND OBJECTIVE: Memantine, a frequently prescribed anti-dementia drug, is mainly eliminated unchanged by the kidneys, partly via tubular secretion. Considerable inter-individual variability in plasma concentrations has been reported. We aimed to investigate clinical and genetic factors influencing memantine disposition. METHODS: A population pharmacokinetic study was performed including data from 108...

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Identifiers

PMID: 23371894
DOI: 10.1007/s40262-013-0032-2

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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