Article
Intranasal delivery of cell-penetrating anti-NF-κB peptides (Tat-NBD) alleviates infection-sensitized hypoxic-ischemic brain injury.
Experimental neurology - 1 Sept 2013
Yang Dianer, Sun Yu-Yo, Lin Xiaoyi, Baumann Jessica M, Dunn R Scott, Lindquist Diana M, Kuan Chia-Yi
Abstract excerpt
Perinatal infection aggravates neonatal hypoxic-ischemic (HI) brain injury and may interfere with therapeutic hypothermia. While the NF-κB signaling pathway has been implicated in microglia activation in infection-sensitized HI, the current therapeutic strategies rely on systemic intervention, which could impair neonatal immunity and increase the risk of severe infection. To devise a brain-targeted anti-NF-κB...
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