Article
Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells.
Nature communications - 1 Jan 2013
Mae Shin-Ichi, Shono Akemi, Shiota Fumihiko, Yasuno Tetsuhiko, Kajiwara Masatoshi, Gotoda-Nishimura Nanaka, Arai Sayaka, Sato-Otubo Aiko, Toyoda Taro, Takahashi Kazutoshi, Nakayama Naoki, Cowan Chad A, Aoi Takashi, Ogawa Seishi, McMahon Andrew P, Yamanaka Shinya, Osafune Kenji
Abstract excerpt
A method for stimulating the differentiation of human pluripotent stem cells into kidney lineages remains to be developed. Most cells in kidney are derived from an embryonic germ layer known as intermediate mesoderm. Here we show the establishment of an efficient system of homologous recombinatio...
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