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Article

Glomerulopathy and mutations in NPHS1 and KIRREL2 in soft-coated Wheaten Terrier dogs.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2013

Littman Meryl P, Wiley Claire A, Raducha Michael G, Henthorn Paula S

Abstract excerpt

Dogs of the soft-coated wheaten terrier breed (SCWT) are predisposed to adult-onset, genetically complex, protein-losing nephropathy (average onset age = 6.3 ± 2.0 years). A genome-wide association study using 62 dogs revealed a chromosomal region containing three statistically significant SNPs (p(raw) ≤ 4.13 × 10(-8); p(genome) ≤ 0.005) when comparing DNA samples from affected and geriatric (≥14 years)...

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Source

Identifiers

PMID: 23325127
DOI: 10.1007/s00335-012-9445-8

Genes

KIRREL2
NPHS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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