Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypertension-susceptibility gene prevalence in the Pacific Islands and associations with hypertension in Melanesia.

Journal of human genetics - 1 Mar 2013

Furusawa Takuro, Naka Izumi, Yamauchi Taro, Natsuhara Kazumi, Eddie Ricky, Kimura Ryosuke, Nakazawa Minato, Ishida Takafumi, Inaoka Tsukasa, Matsumura Yasuhiro, Ataka Yuji, Ohtsuka Ryutaro, Ohashi Jun

Abstract excerpt

Human essential hypertension is partly caused by genetic factors. Angiotensinogen (AGT), G-protein β3-subunit (GNB3) and cytochrome P450 3A5 (CYP3A5) are candidate hypertension susceptibility genes and risk alleles at these loci have been thought to arise owing to human adaptation to climatic cha...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensinogen
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterotrimeric GTP-Binding Proteins

Share to Human Migration

Share to Hypertension

Share to Linkage Disequilibrium

Share to Melanesia

Share to Pacific Islands

Source

Identifiers

PMID: 23324949
DOI: 10.1038/jhg.2012.147

Genes

AGT
GNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23324949-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypertension-susceptibility gene prevalence in the Pacific Islands and associations with hypertension in Melanesia.PMID 23324949Read ↗

Genetic factors contributing to hypertension in African-based populations: A systematic review and meta-analysis.Semantic proximity Read ↗

Identification of a candidate genetic variant for the high prevalence of type II diabetes in Polynesians.Semantic proximity Read ↗

Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature.Semantic proximity Read ↗

Differences in the genotype frequencies of genes related to blood pressure regulation - a comparative study between South-West Europe and Peri-equatorial Africa.Semantic proximity Read ↗

Autosomal and X-linked single nucleotide polymorphisms reveal a steep Asian-Melanesian ancestry cline in eastern Indonesia and a sex bias in admixture rates.Semantic proximity Read ↗

Differential Susceptibility to Hypertension Is Due to Selection during the Out-of-Africa ExpansionSemantic proximity Read ↗

Renin angiotensinogen system gene polymorphisms and essential hypertension among people of West African descent: a systematic review.Semantic proximity Read ↗

Association of APP gene polymorphisms and promoter methylation with essential hypertension in Guizhou: a case-control study.Semantic proximity Read ↗

Polymorphisms associated with a tropical climate and root crop diet induce susceptibility to metabolic and cardiovascular diseases in Solomon Islands.Semantic proximity Read ↗

Unravelling the determinants of human health in French Polynesia: the MATAEA projectSemantic proximity Read ↗

Differences in disease frequency between Europeans and Polynesians: directions for future research into genetic risk factors.Semantic proximity Read ↗

Genetic Variants in the MTHFR and WNK1 Genes and Their Contribution to Hypertension Susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.