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Article

DRD4 and striatal modulation of the link between childhood behavioral inhibition and adolescent anxiety.

Social cognitive and affective neuroscience - 1 Apr 2014

Pérez-Edgar Koraly, Hardee Jillian E, Guyer Amanda E, Benson Brenda E, Nelson Eric E, Gorodetsky Elena, Goldman David, Fox Nathan A, Pine Daniel S, Ernst Monique

Abstract excerpt

Behavioral inhibition (BI), a temperament characterized by vigilance to novelty, sensitivity to approach-withdrawal cues and social reticence in childhood, is associated with risk for anxiety in adolescence. Independent studies link reward hyper-responsivity to BI, adolescent anxiety and dopamine gene variants. This exploratory study extends these observations by examining the impact of DRD4 genotype and reward...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Dopamine D4

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Source

Open in PubMed Open full text

Identifiers

PMID: 23314010
DOI: 10.1093/scan/nst001
PMCID: PMC3989122

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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