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Article

Genetic and epigenetic alterations of steroidogenic factor‑1 in ovarian tumors.

International journal of oncology - 1 Feb 2013

Miller Sarah, Bhasin Nobel, Urrego Heather, Moroz Krzysztof, Rowan Brian G, Ramayya Meera S, Makridakis Nick M

Abstract excerpt

Steroidogenic factor-1 (SF‑1), the product of the NR5A1 gene, is an essential transcription factor that is known to regulate steroidogenesis in ovarian epithelia, including the synthesis of progesterone, a suppressor of ovarian cancer. Expression of the SF‑1 protein, a potential ovarian tumor suppressor, has been demonstrated in normal OSE cells, but is lost in most...

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Source

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Identifiers

PMID: 23291911
DOI: 10.3892/ijo.2012.1758
PMCID: PMC3583749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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