Inhibition of collagen II-induced arthritis in mice--a comparison of the effects of Sch 24937, immunosuppressants and nonsteroidal antiinflammatory drugs on the clinical expression of disease.

doi:10.1016/0192-0561(90)90050-w

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Article

Inhibition of collagen II-induced arthritis in mice--a comparison of the effects of Sch 24937, immunosuppressants and nonsteroidal antiinflammatory drugs on the clinical expression of disease.

International journal of immunopharmacology - 1 Jan 1990

Smith S R, Pennline K J, Bober L A, Kenworthy-Bott L, Phillips L, Pellerito F, da Fonseca M, Terminelli C

Abstract excerpt

Previous studies from this laboratory have described Sch 24937 as a potent immunosuppressive agent that is particularly effective in suppressing humoral immune responses in mice. These findings prompted an evaluation of the effects of Sch 24937 in type II collagen-induced arthritis in mice where disease manifestations include the development of a strong humoral response to the collagen antigen. Sch 24937 reduced...

Topics

Animals
Anti-Inflammatory Agents, Non-Steroidal
Arthritis
Arthritis, Experimental
Betamethasone
Collagen
Immunization
Immunosuppressive Agents
Indoles
Indomethacin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymph Nodes

Lymphocytes

Male

Mice

Phenotype

Pyridines

Spleen

Source

Open in PubMed

Identifiers

PMID: 2329010
DOI: 10.1016/0192-0561(90)90050-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2329010-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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