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Article

Papillary fibroblasts differentiate into reticular fibroblasts after prolonged in vitro culture.

Experimental dermatology - 1 Jan 2013

Janson David, Saintigny Gaëlle, Mahé Christian, El Ghalbzouri Abdoelwaheb

Abstract excerpt

The dermis can be divided into two morphologically different layers: the papillary and reticular dermis. Fibroblasts isolated from these layers behave differently when cultured in vitro. During skin ageing, the papillary dermis decreases in volume. Based on the functional differences in vitro, it is hypothesized that the loss of papillary fibroblasts contributes to skin ageing. In this study, we aimed to mimic...

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Identifiers

PMID: 23278894
DOI: 10.1111/exd.12069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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