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Article

Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jan 2013

Traverse Charles C, Mayo-Smith Leslie M, Poltak Steffen R, Cooper Vaughn S

Abstract excerpt

How diversity evolves and persists in biofilms is essential for understanding much of microbial life, including the uncertain dynamics of chronic infections. We developed a biofilm model enabling long-term selection for daily adherence to and dispersal from a plastic bead in a test tube. Focusing on a pathogen of the cystic fibrosis lung, Burkholderia cenocepacia, we sequenced clones and metagenomes to unravel...

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Identifiers

PMID: 23271804
DOI: 10.1073/pnas.1207025110
PMCID: PMC3549113

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Source receipt: pubmed, retrieved 7 Sept 2026.

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