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Spotlight on NKG 2 C and the human NK ‐cell response to CMV infection

1 Dec 2012

Abstract excerpt

Immune responses to cytomegalovirus (CMV) infection in the mouse and human involve the expansion of specific subsets of natural killer (NK) cells with specific phenotypic characteristics and a heightened ability to produce interferon (IFN)-gamma. In humans, these NK-cell responses are largely driven by the activating receptor NKG2C, which recognize human leukocyte antigen (HLA)-E in complex with leader sequence...

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PMID: 23255011
DOI: 10.1002/eji.201243050

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