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Article

Glucocorticoids Affect 24 h Clock Genes Expression in Human Adipose Tissue Explant Cultures

10 Dec 2012

Abstract excerpt

AIMS: to examine firstly whether CLOCK exhibits a circadian expression in human visceral (V) and subcutaneous (S) adipose tissue (AT) in vitro as compared with BMAL1 and PER2, and secondly to investigate the possible effect of the glucocorticoid analogue dexamethasone (DEX) on positive and negative clock genes expression. SUBJECTS AND METHODS: VAT and SAT biopsies were obtained from morbid obese women (body mass...

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PMID: 23251369
DOI: 10.1371/journal.pone.0050435

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