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Article

Side population in human non-muscle invasive bladder cancer enriches for cancer stem cells that are maintained by MAPK signalling.

PloS one - 1 Jan 2012

Hepburn Anastasia C, Veeratterapillay Rajan, Williamson Stuart C, El-Sherif Amira, Sahay Neha, Thomas Huw D, Mantilla Alejandra, Pickard Robert S, Robson Craig N, Heer Rakesh

Abstract excerpt

Side population (SP) and ABC transporter expression enrich for stem cells in numerous tissues. We explored if this phenotype characterised human bladder cancer stem cells (CSCs) and attempted to identify regulatory mechanisms. Focusing on non-muscle invasive bladder cancer (NMIBC), multiple human cell lines were used to characterise SP and ABC transporter expression. In vitro and in vivo phenotypic and functional...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to MAP Kinase Signaling System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Grading

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Source

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Identifiers

PMID: 23226356
DOI: 10.1371/journal.pone.0050690
PMCID: PMC3511341

Genes

ABCG2
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Side population in human non-muscle invasive bladder cancer enriches for cancer stem cells that are maintained by MAPK signalling.PMID 23226356Read ↗

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