Article
A thyroid peroxidase (TPO) mutation in dogs reveals a canid-specific gene structure.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2013
Fyfe John C, Lynch Mary, Olsen Jayme, Louёr Eric
Abstract excerpt
Congenital hypothyroidism with goiter (CHG) occurring as an autosomal recessive disorder is typically due to a defect of thyroid hormone synthesis (aka dyshormonogenesis). Thyroid peroxidase (TPO) is a multifunctional, heme-containing enzyme whose activity is required, and several inactivating TPO mutations causing CHG in humans and dogs have been described. Recently, two half-sib Spanish water dog (SWD) pups...
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