Article
Gene-environment interactions for breast cancer risk among Chinese women: a report from the Shanghai Breast Cancer Genetics Study.
American journal of epidemiology - 15 Jan 2013
Li Haixin, Beeghly-Fadiel Alicia, Wen Wanqing, Lu Wei, Gao Yu-Tang, Xiang Yong-Bing, Cai Qiuyin, Long Jirong, Shi Jiajun, Chen Kexin, Zheng Ying, Shu Xiao Ou, Zheng Wei
Abstract excerpt
Genome-wide association studies have identified approximately 20 susceptibility loci for breast cancer. A cumulative genetic risk score (GRS) was constructed from 10 variants with replicated associations among participants of the Shanghai Breast Cancer Genetics Study (Shanghai, China, 1996-1998 and 2002-2005). Interactions between the GRS and 11 breast cancer risk factors were evaluated. Among the 6,408 study...
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