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Article

Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.

Nucleic acids research - 1 Jan 2013

Piazzon Nathalie, Schlotter Florence, Lefebvre Suzie, Dodré Maxime, Méreau Agnès, Soret Johann, Besse Aurore, Barkats Martine, Bordonné Rémy, Branlant Christiane, Massenet Séverine

Abstract excerpt

Spinal muscular atrophy is a severe motor neuron disease caused by reduced levels of the ubiquitous Survival of MotoNeurons (SMN) protein. SMN is part of a complex that is essential for spliceosomal UsnRNP biogenesis. Signal recognition particle (SRP) is a ribonucleoprotein particle crucial for co-translational targeting of secretory and membrane proteins to the endoplasmic reticulum. SRP biogenesis is a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23221635
DOI: 10.1093/nar/gks1224
PMCID: PMC3553995

Genes

SRP54

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.PMID 23221635Read ↗

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