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Article

Porcine reproductive and respiratory syndrome virus ORF5a protein is essential for virus viability.

Virus research - 1 Jan 2013

Sun Lichang, Li Yanhua, Liu Runxia, Wang Xiaomin, Gao Fei, Lin Tao, Huang Ting, Yao Huochun, Tong Guangzhi, Fan Hongjie, Wei Zuzhang, Yuan Shishan

Abstract excerpt

It has been shown that ORF5a protein in EAV is important but not essential for virus infectivity. In this study, we found that RNA changes in the overlapping region (1-104 nucleotide, nt) between ORF5 and ORF5a introduced by codon-optimized GP5 was lethal for virus viability, suggesting that the...

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Identifiers

PMID: 23219923
DOI: 10.1016/j.virusres.2012.11.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23219923-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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