Article
Early metabolic defects in Arab subjects with strong family history of Type 2 diabetes.
Journal of endocrinological investigation - 1 Jun 2013
Shalata A, Jazmawi W, Aslan O, Badarni K, Dabbah K, Sawaed S, Cohen Castel O, Borochowitz Z U, Karkabi K, Defronzo R, Abdul-Ghani M
Abstract excerpt
AIMS AND OBJECTIVE: It is widely accepted that the genetic make-up of the subject plays a pivotal role in the development of insulin resistance and β cell failure. The objective of this study was to examine whether the same or distinct genetic backgrounds contribute to the development of insulin resistance and β cell failure. METHODS: We examined insulin sensitivity and β cell function in lean normal glucose...
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