Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of expression of the proteins GMPR2 and PPARα are associated with the basal phenotype and patient outcome in breast cancer.

Breast cancer research and treatment - 1 Jan 2013

Baker B G, Ball G R, Rakha E A, Nolan C C, Caldas C, Ellis I O, Green A R

Abstract excerpt

UNLABELLED: Basal-like tumours (BP) are a poor prognostic class of breast cancer but remain a biologically and clinically heterogeneous group. We have previously identified two novel genes PPARα (positive) and GMPR2 (negative) whose expression was significantly associated with BP at the transcriptome level. In this study, using a large and well-characterised series of operable invasive breast carcinomas (1,043...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Carcinoma, Ductal, Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease-Free Survival

Share to Kaplan-Meier Estimate

Share to Lymphatic Metastasis

Share to Multivariate Analysis

Share to PPAR alpha

Share to Proportional Hazards Models

Source

Identifiers

PMID: 23208589
DOI: 10.1007/s10549-012-2302-3

Genes

GMPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Lack of expression of the proteins GMPR2 and PPARα are associated with the basal phenotype and patient outcome in breast cancer.PMID 23208589Read ↗

Basal phenotype identifies a poor prognostic subgroup of breast cancer of clinical importance.Semantic proximity Read ↗

Breast carcinoma with basal differentiation: a proposal for pathology definition based on basal cytokeratin expression.Semantic proximity Read ↗

Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers--results of a large scale microarray analysis.Semantic proximity Read ↗

The localisation and reduction of nuclear staining of PPARγ and PGC-1 in human breast cancerSemantic proximity Read ↗

Cytoplasmic PPARγ is a marker of poor prognosis in patients with Cox-1 negative primary breast cancersSemantic proximity Read ↗

Opposing roles for mammary epithelial-specific PPARγ signaling and activation during breast tumour progressionSemantic proximity Read ↗

Ligand-activated PPARγ downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progressionSemantic proximity Read ↗

Expression of oestrogen receptor-β in oestrogen receptor-α negative human breast tumoursSemantic proximity Read ↗

The PPARgamma antagonist T0070907 suppresses breast cancer cell proliferation and motility via both PPARgamma-dependent and -independent mechanisms.Semantic proximity Read ↗

Investigating AP-2 and YY1 protein expression as a cause of high HER2 gene transcription in breast cancers with discordant HER2 gene amplificationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.