Article
Polymorphisms in thymic stromal lymphopoietin gene demonstrate a gender and nasal polyposis-dependent association with chronic rhinosinusitis.
Human immunology - 1 Feb 2013
Zhang Yuan, Wang Xiangdong, Zhang Wei, Han Demin, Zhang Luo, Bachert Claus
Abstract excerpt
BACKGROUND: Recent studies have suggested that thymic stromal lymphopoietin (TSLP), a key cytokine involved in the dendritic cell-mediated activation of Th2-mediated inflammatory responses, is significantly increased in nasal polyps from atopic individuals. Our objective was therefore to explore firstly any associations between single nucleotide polymorphisms (SNPs) in and around the TSLP gene and development of...
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