Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma.

Nature communications - 10 Nov 2025

Saarentaus Elmo C, Fischer-Rasmussen Kasper, Sliz Eeva, Bizaki-Vallaskangas Argyro, Laitinen Tarja, Toppila-Salmi Sanna, Kankaanranta Hannu, Kettunen Johannes, Bønnelykke Klaus, Palotie Aarno, Mäkitie Antti

Abstract excerpt

The coexistence of asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP) is associated with allergic phenotypes, disease severity and failure of first-line treatment for both asthma and CRSwNP. Recent studies have highlighted shared genetic components for these diseases. To better understand this shared component, we perform genome-wide meta-analyses of asthma (n = 71,481), CRSwNP (n = 9626) and chronic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Polymorphism, Single Nucleotide
Share to Asthma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chronic Disease

Share to Forkhead Transcription Factors

Share to Genetic Loci

Share to Genome-Wide Association Study

Share to Nasal Polyps

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 41213931
DOI: 10.1038/s41467-025-64847-4
PMCID: PMC12603121

Genes

FOXP3
TP63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma.PMID 41213931Read ↗

131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthmaSemantic proximity Read ↗

Comparative genomic analysis reveals shared and distinct mechanisms of nasal polyps and chronic rhinosinusitisSemantic proximity Read ↗

Distinct Type 2-high Inflammation Associated Molecular Signatures of Chronic Rhinosinusitis with Nasal Polyps with Comorbid AsthmaSemantic proximity Read ↗

Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosaSemantic proximity Read ↗

Familial risk of chronic rhinosinusitis with and without nasal polyposis: genetics or environmentSemantic proximity Read ↗

Genetic Evidence for Unified Airway Disease: Shared Epithelial and Immune Architecture Across Major Airway Diseases.Semantic proximity Read ↗

Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation.Semantic proximity Read ↗

A family-based genome-wide association study of chronic rhinosinusitis with nasal polyps implicates several genes in the disease pathogenesis.Semantic proximity Read ↗

Single-nucleotide polymorphism in chronic rhinosinusitis: A systematic review.Semantic proximity Read ↗

Heterogeneity of asthma with nasal polyposis phenotypes: A cluster analysis.Semantic proximity Read ↗

Genetic evidence for a role of IL33 in nasal polyposis.Semantic proximity Read ↗

Two‐stage genome‐wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to riskSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.