Article
A new mutant transcript generated in Znf230 exon 2 knockout mice reveals a potential exon structure in the targeting vector sequence.
Acta biochimica et biophysica Sinica - 1 Feb 2013
Liu Yunqiang, Tao Dachang, Ma Sunkai, Kuang Ying, Su Dan, Zhang Hao, Yang Yuan, Ma Yongxin, Zhang Sizhong
Abstract excerpt
Testis gene Znf230 may play a role in mammalian spermatogenesis according to previous reports. Deleting 5' important exons to block the formation of protein was a routine way in gene-knockout experiments. To investigate the physiological function of Znf230 gene, the mutant mice with disrupted exon 2 of Znf230 were generated in this study. Results showed that, mutant Znf230 mice were fertile and showed normal...
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