Article
New treatments on the horizon for familial hypercholesterolemia.
Expert review of cardiovascular therapy - 1 Oct 2012
Allian-Sauer Marybeth U, Falko James M
Abstract excerpt
Patients with familial hypercholesterolemia (FH) have higher baseline LDL cholesterol (LDLc) levels and are at high risk of developing premature cardiovascular disease. Disease is attributed to mutations in the LDLR gene, which encodes the LDL receptor protein and whose deficiency results in decreased uptake of apoB-containing cholesterol particles by the liver and elevated serum LDLc levels. Heterozygous FH is...
Topics
- Age Factors
- Animals
- Anticholesteremic Agents
- Blood Component Removal
- Cardiovascular Diseases
- Cholesterol, LDL
- Disease Progression
- Drug Design
- Humans
- Hyperlipoproteinemia Type II
- Mutation