The influence of novel transcriptional regulatory element in intron 14 on the expression of Janus kinase 2 gene in myeloproliferative neoplasms.

doi:10.1007/s13353-012-0125-x

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Article

The influence of novel transcriptional regulatory element in intron 14 on the expression of Janus kinase 2 gene in myeloproliferative neoplasms.

Journal of applied genetics - 1 Feb 2013

Spasovski Vesna, Tosic Natasa, Nikcevic Gordana, Stojiljkovic Maja, Zukic Branka, Radmilovic Milena, Karan-Djurasevic Teodora, Srzentic Sanja, Colovic Milica, Pavlovic Sonja

Abstract excerpt

The expression of Janus kinase 2 (JAK2) gene is altered in myeloproliferative neoplasms (MPN) and the regulation of transcription could be a mechanism that modulates JAK2 gene expression. We analyzed the transcriptional potential of single-nucleotide polymorphism (SNP) rs12343867 T > C in JAK2 intron 14, tagging 46/1 haplotype, and its influence on JAK2 gene expression. Functional analysis of JAK2 intron 14 was...

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PMID: 23188718
DOI: 10.1007/s13353-012-0125-x

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JAK2

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