Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aberrant upregulation of ASCL 2 by promoter demethylation promotes the growth and resistance to 5‐fluorouracil of gastric cancer cells

26 Nov 2012

Abstract excerpt

Achaete scute-like 2 (ASCL2), a basic helix-loop-helix transcription factor, plays an essential role in the maintenance of adult intestinal stem cells. However, the function of ASCL2 in gastric cancer (GC) is poorly understood. Therefore, we investigated the roles and regulatory transcription mechanisms of ASCL2 in GC. Gene expression and methylation data analysis showed that ASCL2 was upregulated and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to DNA Repair Mechanisms
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23181270
DOI: 10.1111/cas.12076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aberrant upregulation of ASCL 2 by promoter demethylation promotes the growth and resistance to 5‐fluorouracil of gastric cancer cellsPMID 23181270Read ↗

TET2–BCLAF1 transcription repression complex epigenetically regulates the expression of colorectal cancer gene Ascl2 via methylation of its promoterSemantic proximity Read ↗

Long noncoding AGAP2-AS1 is activated by SP1 and promotes cell proliferation and invasion in gastric cancerSemantic proximity Read ↗

lncRNA DLEU2 promotes gastric cancer progression through ETS2 via targeting miR-30a-5pSemantic proximity Read ↗

Expression Characteristics and Biological Functional Role of FLG in Gastric CancerSemantic proximity Read ↗

AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNASemantic proximity Read ↗

Capillary morphogenesis gene 2 maintains gastric cancer stem-like cell phenotype by activating a Wnt/β-catenin pathway.Semantic proximity Read ↗

Identification of ALYREF in pan cancer as a novel cancer prognostic biomarker and potential regulatory mechanism in gastric cancerSemantic proximity Read ↗

Tissue transglutaminase-1 promotes stemness and chemoresistance in gastric cancer cells by regulating Wnt/β-catenin signalingSemantic proximity Read ↗

Stem cells in gastric cancer.Semantic proximity Read ↗

Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinibSemantic proximity Read ↗

MAGEA4 promotes gastric cancer progression by inducing chromosomal instability through the STAU1/c-Myc axisSemantic proximity Read ↗

SALL4, a novel marker for human gastric carcinogenesis and metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.