Article
ZNF512B gene is a prognostic factor in patients with amyotrophic lateral sclerosis.
Journal of the neurological sciences - 15 Jan 2013
Tetsuka Syuichi, Morita Mitsuya, Iida Aritoshi, Uehara Ritei, Ikegawa Shiro, Nakano Imaharu
Abstract excerpt
Recently, Iida et al. discovered a new single-nucleotide polymorphism (SNP) in the ZNF512B gene associated with susceptibility to amyotrophic lateral sclerosis (ALS). The ZNF512B gene was found to be a transcription factor promoting the expression of a downstream gene in the signal transduction pathway of the transforming growth factor-β (TGF-β), which is essential for the protection and survival of neurons but...
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