HCV genotype 1a shows a better virological response to antiviral therapy than HCV genotype 1b.

doi:10.1186/1471-230X-12-162

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Article

HCV genotype 1a shows a better virological response to antiviral therapy than HCV genotype 1b.

BMC gastroenterology - 16 Nov 2012

Pellicelli Adriano M, Romano Mario, Stroffolini Tommaso, Mazzoni Ettore, Mecenate Fabrizio, Monarca Roberto, Picardi Antonio, Bonaventura Maria Elena, Mastropietro Cristina, Vignally Pascal, Andreoli Arnaldo, Marignani Massimo, D'Ambrosio Cecilia, Miglioresi Lucia, Nosotti Lorenzo, Mitidieri Olga, Gentilucci Umberto Vespasiani, Puoti Claudio, Barbaro Giuseppe, Barlattani Angelo, Furlan Caterina, Barbarini Giorgio

Abstract excerpt

BACKGROUND: The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively investigated. The aim of this study is to determine whether the HCV genotype 1 subtypes 1a and 1b respond differently to treatment with PEGylated interferon (PEG-IFN) plus ribavirin. METHODS: For 48...

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PMID: 23157720
DOI: 10.1186/1471-230X-12-162
PMCID: PMC3526494

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