Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN.

doi:10.18632/oncotarget.694

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Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN.

Oncotarget - 1 Nov 2012

Beggs Andrew D, Domingo Enric, McGregor Megan, Presz Mikael, Johnstone Elaine, Midgley Rachel, Kerr David, Oukrif Dahmane, Novelli Marco, Abulafi Muti, Hodgson Shirley V, Fadhil Wakkas, Ilyas Mohammad, Tomlinson Ian P M

Abstract excerpt

Repair of double strand DNA breaks (DSBs) is pivotal in maintaining normal cell division and disruption of this system has been shown to be a key factor in carcinogenesis. Loss of expression of the DSB repair proteins have previously been shown to be associated with poorer survival in colorectal cancer. We wished to ascertain the relationship of altered expression of the DSB repair proteins γ-H2AX (gamma-H2AX),...

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Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN.

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