Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[The molecular mechanism of haemophilia B caused by the Arg327Ile novel mutation in FIX gene in vitro expression].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Aug 2012

Zhou Jia-wei, Dai Jing, Ding Qiu-lan, Yu Ting-ting, Lu Ye-ling, Wang Xue-feng, Wang Hong-li

Abstract excerpt

OBJECTIVE: To investigate the molecular mechanism of haemophilia B caused by the novel mutation of Arg327Ile (R327I) in FIX gene. METHODS: The R327I, R327Ala(A), R327Lys(K), R327Asn(N) and a replacement mutant (FIXβFVII), in which FIX β strand 324-329 was replaced by that of FVII 298-303, expression plasmids were constructed with site-directed mutagenesis method based on the wild-type (WT) FIX expression plasmid....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Factor IX
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemophilia B

Share to Mutagenesis, Site-Directed

Share to Mutation

Share to Transfection

Source

Identifiers

PMID: 23134860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[The molecular mechanism of haemophilia B caused by the Arg327Ile novel mutation in FIX gene in vitro expression].PMID 23134860Read ↗

The Molecular Basis of FIX Deficiency in Hemophilia B.Semantic proximity Read ↗

Characterization of missense mutations in the signal peptide and propeptide of FIX in hemophilia B by a cell-based assaySemantic proximity Read ↗

[Molecular pathogenesis of haemophilia A].Semantic proximity Read ↗

Structural and functional exploration of three newly identified coagulation factor IX mutations in Chinese hemophilia B patients.Semantic proximity Read ↗

Coagulation Factor IX for Hemophilia B TherapySemantic proximity Read ↗

[Hemophilia B replacement therapy drugs].Semantic proximity Read ↗

A new hemophilia B mutation in the propeptide region of the FIX gene.Semantic proximity Read ↗

[The current feature of the study on human coagulation factor IX mutant].Semantic proximity Read ↗

Usefulness of an in vitro cellular expression model for haemophilia A carrier diagnosis: illustration with five novel mutations in the F8 gene in women with isolated factor VIII:C deficiency.Semantic proximity Read ↗

[The binding mechanisms of F VIII Trp1707Ser mutation-associated inhibitor].Semantic proximity Read ↗

[Study on the impact of Trp1707Ser mutation on the binding mechanism of rF VIII light chain with VWF].Semantic proximity Read ↗

[Gene diagnosis of 3 haemophilia B families].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.