Article
Autoantibodies and decreased expression of the transcription factor ELF-3 together with increased chemokine pathways support an autoimmune phenotype and altered differentiation in lichen planus located in oral mucosa.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Nov 2013
Danielsson K, Boldrup L, Rentoft M, Coates P J, Ebrahimi M, Nylander E, Wahlin Y B, Nylander K
Abstract excerpt
BACKGROUND: The pathogenesis of oral lichen planus (OLP), a chronic inflammatory disease, is not fully understood. It is known that OLP has autoimmune features, and it is suggested to be an autoimmune disease. ELF-3 is involved in differentiation of keratinocytes and deregulated in different tumours and inflammatory diseases. CXCR-3 and its ligands CXCL-10 and CXCL-11 are increased in autoimmune diseases and...
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