Genetic testing in heritable cardiac arrhythmia syndromes: differentiating pathogenic mutations from background genetic noise.

Abstract excerpt

PURPOSE OF REVIEW: In this review, we summarize the basic principles governing rare variant interpretation in the heritable cardiac arrhythmia syndromes, focusing on recent advances that have led to disease-specific approaches to the interpretation of positive genetic testing results. RECENT FINDINGS: Elucidation of the genetic substrates underlying heritable cardiac arrhythmia syndromes has unearthed new...

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