Article
Identification of Bangladeshi domestic cats with GM1 gangliosidosis caused by the c.1448G>C mutation of the feline GLB1 gene: case study.
The Journal of veterinary medical science - 1 Jan 2013
Uddin Mohammad Mejbah, Hossain Mohammad Alamgir, Rahman Mohammad Mahbubur, Chowdhury Morshedul Alam, Tanimoto Takeshi, Yabuki Akira, Mizukami Keijiro, Chang Hye-Sook, Yamato Osamu
Abstract excerpt
GM1 gangliosidosis is a fatal, progressive neurodegenerative lysosomal storage disease caused by mutations in the β-galactosidase (GLB1) gene. In feline GM1 gangliosidosis, a pathogenic mutation (c.1448G>C) in the feline GLB1 gene was identified in Siamese cats in the United States and Japan and in Korat cats in Western countries. The present study found the homozygous c.1448G>C mutation in 2 apparent littermate...
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